The lowest ranked side remaining in the competition, Colchester are paired to play Manchester United in the League Cup quarterfinal.
Fourth-tier Colchester United’s chairman was said to have expressed his delight at being drawn away at Manchester United.
“You come into football for days like this,” he said
Colchester lost both times they faced United: 1-0 in the FA Cup fifth round in 1978-79 and 2-0 in the League Cup third round in 1983-84.
Colchester knocked out last season’s Champions League finalists Tottenham Hotspur in the third round and looking forward to give Man Utd a surprise.
Holders Manchester City also will be playing lower-league opposition as they travel to third tier Oxford United.
Only two Premier League side will be facing each other as Aston Villa gets to host Liverpool and Everton hosts Leicester City too.
Meanwhile Jurgen Klopp has threatened to call a halt to his side’s participation because the quarterfinal is too close to the Fifa World Club Cup.
However, the EFL – organisers of the League Cup – released a statement saying they were talking to Liverpool about an alternative date.
“The EFL is in discussions with Liverpool to identify an alternative date given the club’s participation in the Fifa Club World Cup competition,” they said.
Liverpool will be playing in the semifinals in Qatar on December 18 and the League Cup quarterfinals are scheduled for that week.
Aston Villa v Liverpool
Everton v Leicester City
Manchester United v Colchester United
Oxford v Manchester City